Psilocybin and psilocin are two closely related mind-altering substances found in certain species of mushrooms, commonly referred to as mind-expanding mushrooms truffle. These natural remedies have been utilized for centuries and ceremonial uses, particularly in tribal societies of the Americas, where they played a significant role in the traditional practices of Mesoamerican cultures.

The mechanisms of action are still unknown, but much research has been conducted to reveal their effects on the brain. Psilocybin and psilocin are a type of psychoactive agents, similar to MDMA.

When psilocybin is ingested, it is rapidly metabolized into psilocin by an enzyme called monoamine oxidase. Psilocin then connects with the 5-HT2A receptor, leading to altered perception. This activation leads to the release of neurotransmitters, such as dopamine and norepinephrine.

The actions of psilocybin and psilocin are characterized by changes in neural pathways. One such system is the salience network, involved in stimulus detection and evaluation.

Psilocybin and psilocin have been shown to reduce activity in the DMN, leading to a decrease in self-centered thinking.

Another key process affected is the emotional regulation network, involved in emotional processing.

In addition to their influence on brain function, psilocybin and psilocin have been found to have significant effects on mood and behavior.

Clinical trials have demonstrated potential therapeutic benefits.

The potential benefits of psilocybin and psilocin have been identified.

More studies are required to uncover the mechanisms of action.

However, available research indicates that psilocybin and psilocin may have significant therapeutic benefits.